Glucosamine injection for the ankle
With chondroitin and hyaluronic acid, in one pre-filled syringe.
The ankle
The ankle is a hinge. The lower ends of the two shin bones sit over the dome of the talus, the bone that links the leg to the foot, with cartilage and joint fluid between them.
Ankle osteoarthritis is less common than in the knee or hip and usually follows an old fracture or repeated sprains rather than wear alone. The joint stiffens and hurts on walking, especially on uneven ground.
How it tends to show
- Pain across the front of the ankle on walking, worse on slopes or rough ground.
- Stiffness after rest and a smaller range of movement than the other ankle.
- Swelling over the front of the joint after activity.
- A past ankle fracture or repeated sprains on that side.
Application
The needle is placed into the front of the ankle joint, usually with ultrasound guidance because the joint space is narrow. One pre-filled syringe is injected. The manufacturer describes two treatment cycles a year, six months apart.2
Other joints
Studies mentioned on this page
- 1.Nikovari Bio Tech Oy. Bioport TriCombo instructions for use. Supplied with each pack, 2025. View source
- 2.Nikovari Bio Tech Oy. Bioport TriCombo product brochure. Manufacturer document, 8 pages, 2025. View source
- 3.Iordan DA, Coman MG, Hrisca-Eva OD, Stavrică-George A, Gherghin AC, Onu I. Enhanced Synovial Fluid Rheology in Moderate Knee Osteoarthritis Through Combined Intra-Articular Hyaluronic Acid and Multimodal Physiotherapy: A Monocentric Observational Study. Journal of Clinical Medicine, 14(17):6051, 2025. View DOI
Talk to a clinic
This website gives information, not clinical advice. Only a clinician who has examined your ankle can say whether TriCombo is an option for you.