BioportTriComboUK patient and professional information

Glucosamine injection for the shoulder

With chondroitin and hyaluronic acid, in one pre-filled syringe.

Illustration of the shoulder joint from the front, with a needle placed into the joint space between the head of the arm bone and the shoulder blade

In short

  • Indicated for synovial joints, which include the shoulder.1
  • Studied in the knee.3
  • Three ingredients, one pre-filled syringe, one injection per treatment.2
  • Whether it is an option for you is decided by the clinician who examines your shoulder.

The shoulder

The shoulder is the most mobile joint in the body. The ball at the top of the arm bone rests against a shallow socket on the shoulder blade, held by muscles and a capsule rather than by deep bone.

Osteoarthritis of the shoulder joint itself, the glenohumeral joint, wears the cartilage on the ball and the socket. It is less common than knee or hip osteoarthritis, and shoulder pain more often comes from the tendons around the joint, which this injection is not intended for.

How it tends to show

  • A deep ache in the shoulder that is worse with use and at night.
  • Stiffness, with less reach behind the back or overhead than before.
  • Grinding or clicking from inside the joint on movement.
  • Pain that has not settled with time, exercises or a steroid injection.

Application

The clinician confirms that the pain is coming from the shoulder joint and not the tendons around it, usually with imaging. One pre-filled syringe is injected into the joint space, often with ultrasound guidance. The manufacturer describes two treatment cycles a year, six months apart.2

Bioport TriCombo pack and pre-filled syringe

Research

TriCombo’s published clinical study is in the knee: a 2025 single-centre study of Kombihylan, the combination the manufacturer names as TriCombo’s active principles, which measured the properties of the joint fluid six weeks after injection.3,2

The knee study, for professionals

Other joints

Studies mentioned on this page

  1. 1.Nikovari Bio Tech Oy. Bioport TriCombo instructions for use. Supplied with each pack, 2025. View source
  2. 2.Nikovari Bio Tech Oy. Bioport TriCombo product brochure. Manufacturer document, 8 pages, 2025. View source
  3. 3.Iordan DA, Coman MG, Hrisca-Eva OD, Stavrică-George A, Gherghin AC, Onu I. Enhanced Synovial Fluid Rheology in Moderate Knee Osteoarthritis Through Combined Intra-Articular Hyaluronic Acid and Multimodal Physiotherapy: A Monocentric Observational Study. Journal of Clinical Medicine, 14(17):6051, 2025. View DOI

Talk to a clinic

This website gives information, not clinical advice. Only a clinician who has examined your shoulder can say whether TriCombo is an option for you.

Where to have itFAQ